The goal of our research is to identify the fundamental mechanisms that govern neuronal cell death and connectivity of neural circuits in mammalian brain development and disease and to determine how these mechanisms are deregulated in neurological diseases. In addition, we are now focused on the elucidation of the mechanisms regulating the morphogenesis of axons, dendrites, and synapses and CNS axon regeneration after injury.
학력
(Ph.D.) 2000. Department of Biology, Hallym University
약력/경력
2005-Present: Assistant, Associate, Full Professor, Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine
2011?2012 Visiting Professor, Department of Neurology, University of California, School of Medicine, San Francisco, CA, USA
2002-2005: Post doctoral Fellow, Department of Pathology and Laboratory, school of Medicine, Emory University Atlanta, GA, U.S.A.
학술지 논문
(2023)
PARIS undergoes liquid–liquid phase separation and poly(ADP-ribose)-mediated solidification.
EMBO REPORTS.
24,
11
(2023)
Exploration of Mechanisms of DrugResistance in a Microfluidic Device andPatient Tissues
Wanyoung Lim,.
ELIFE.
1,
1
(2023)
PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia.
AUTOPHAGY.
20,
2
(2023)
Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice.
FRONTIERS IN AGING NEUROSCIENCE.
14,
(2022)
Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice.
MOLECULAR PSYCHIATRY.
27,
4
(2021)
Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
SCIENTIFIC REPORTS.
11,
1
(2021)
Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating alpha K40 acetylation of alpha-tubulin.
CELL DEATH DISCOVERY.
7,
257
(2021)
EBP1 regulates Suva stability via the ubiquitin-proteasome system in neural development.
BMB REPORTS.
1,
1
(2020)
The roles of multifunctional protein ErbB3 binding protein 1 (EBP1) isoforms from development to disease.
EXPERIMENTAL AND MOLECULAR MEDICINE.
52,
7
(2020)
Dysregulation of Epigenetic Control Contributes to Schizophrenia-Like Behavior in Ebp1(+/-) Mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
7
(2019)
Roles of ErbB3-binding protein 1 (EBP1) in embryonic development and gene-silencing control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
116,
49
(2019)
SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.
JOURNAL OF BIOLOGICAL CHEMISTRY.
294,
42
(2019)
B23/Nucleophosmin promotes reconstitution of synaptic path in hippocampus after injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
508,
4
(2018)
Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling.
STEM CELL RESEARCH & THERAPY.
9,
(2018)
Chaperone-E3 Ligase Complex HSP70-CHIP Mediates Ubiquitination of Ribosomal Protein S3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
19,
9
(2018)
PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice.
CELL DEATH & DISEASE.
9,
876
(2018)
Vascular endothelial growth factor in mediating therapeutic efficacy of mesenchymal stem cell derived exosomes against neonatal hyperoxic lung injury.
EXPERIMENTAL AND MOLECULAR MEDICINE.
50,
26
(2018)
Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation.
SCIENTIFIC REPORTS.
8,
2557
(2018)
Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders.
PEDIATRIC RESEARCH.
83,
1
(2017)
Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy) methyl) azetidine hydrochloride on beta-amyloid-induced microglial activation.
BMB REPORTS.
50,
12
수상/공훈
2013, 제13회 동천신진과학자상 (한국생화학분자생물학회)
2013, 제23회 과학기술 우수논문상 (한국과학기술단체총연합회)
학술회의논문
(2018)
The E3 ligase SIAH regulates ubiquitination and degradation of Akt3.
2018 Society for Neuroscience annual meeting.
미국
(2018)
Ebp1 deficient mice cause Purkinje cells dysfunction and autistic-like behavior.
2018 Society for Neuroscience annual meeting.
미국
(2018)
Id2 regulates axon elongation, controlling α-tubulin acetylation.
2018 Society for Neuroscience annual meeting.
미국
(2018)
Ebp1 is essential for Purkinje cell deveopment by enhancing stability of Ptf1a.
한국뇌신경과학회 연례학술회의.
대한민국
(2018)
Id2 controls microtubule stabilizing and architecture through the regulation of α-tubulin acetylation..
한국뇌신경과학회 연례 학술대회.
대한민국
(2018)
Cerebellar dysfunction casues motor impairment and autistic like behavior in Ebp1 deficient mice.
한국분자세포생물학회 단백질 대사분과.
대한민국
(2017)
Intrinsic control of Akt signaling in CNS axon growth and regeneration by regulation of novel substrates,Radixin and Id2.
2017 ISN-ESN meeting.
프랑스
(2017)
AKT/PKB signaling regulates neurite outgrowth controlling radixin stability..
KSBMB International conference 2017.
대한민국
(2017)
Ebp1 is crucial regulator of Purkinje and granule neurons
generation in cerebellum development.
KSBMB International conference 2017.
대한민국
(2016)
Phosphorylaiton of Id2 by protein kinase B/Akt signaling regulates axon growth and axon regeneration by contributing to growth cone formation.
the 14th protein metabolosm and diseases conference.
대한민국
(2016)
Regulation of neuronal death and connectivity by protein modification.
The 14th protein metabolism and diseases conference.
대한민국
(2016)
Akt signaling regulates CNS axon cotrolling through growth cone formation.
KSBMB international conference.
대한민국
(2016)
C-terminal domain of p42Ebp1 is sufficient to inhibit cancerous growth of gliomablastoma by inhibiting PI3K.
KSBMB international conference.
대한민국
(2015)
A novel mechanism of Id2 in cntrolling neurie outgrowth.
The 10th protein metabolosm and diseases conference.
대한민국
(2015)
SIAH1 mediates ubiquitination and degradation of PKB/AKt in axonal growth regulation.
The 13th protein metabolism and disease conference.
대한민국
